Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, United States ...

Parkinson’s disease affects more than 10 million people worldwide. Discover its causes, symptoms, and the latest innovations ...

NCoR1/RARα interaction was identified as a target for selective chaperone-mediated autophagy (CMA) inhibition in lung cancer.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, China School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Key Laboratory of ...

Abbreviations: full, complete alae; n, number of animal sides examined; ND, not determined; no, no alae; partial, gaps in alae. Animals containing sea‐2(bp283) were grown at 15 °C. P‐values are ...

In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and ...

Dr. Dash says, "Our study reveals a unique PARK7 secretion mechanism, which relies on the coordinated actions of both macroautophagy and chaperone-mediated autophagy (CMA). Under oxidative stress ...

Autophagy can be classified into three distinct forms based on its physiological functions and the pathways leading the lysosomal delivery: macroautophagy, microautophagy, and chaperone-mediated ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Autophagy, traditionally known for degrading and recycling cytoplasmic components to maintain cellular homeostasis, has recently emerged as a novel route for the unconventional secretion of ...