This research roundup discusses researchers’ attempts to find a treatment for a “brain fog” that comes with CAR T-Cell ...

The near-extinct northern white rhino could be revived following a "crucial" genome breakthrough. It is one of the rarest ...

In the study, "Targeting the SHOC2–RAS interaction in RAS-mutant cancers," published in Nature, researchers conducted a genome-wide CRISPR screen to identify genetic dependencies associated with ...

We conducted a genome-wide CRISPR screen to uncover essential regulators of cardiomyocyte specification in human embryonic stem cells using a myosin heavy chain ... and wet laboratory support. B.C.L.

As hemophilia B is caused by mutations in the F9 gene, which encodes a clotting protein called factor IX (FIX), Regeneron’s drug candidate uses CRISPR/Cas9 gene editing to place a copy of the F9 gene ...

The EDVs contained the CRISPR machinery to knock out the native T-cell receptor, and a transgene for a receptor that targets B cells, which were used as a ... with a framework for using CRISPR to ...

"It is well known that CRISPR can result in spurious genetic modifications with unknown consequences to the treated cells," David Rueda, chair of Molecular and Cellular Biophysics at Imperial ...

Using a new CRISPR-based methodology for modulating DNA structure to enact epigenetic control over specific genes, a team of researchers has identified a “master regulator” gene capable of improving T ...

The phase 1 clinical trial led by Dr. Park uses the CRISPR-edited CAR T cells to treat diffuse large B cell lymphoma, the most common type of non-Hodgkin lymphoma. The CAR T cells target a protein on ...

Methods: We have used CRISPR/Cas9 technology in primary B cells to screen for regulators of terminal differentiation and antibody production. Discussion: The genes identified in this study represent ...