The beginning of a synaptic terminal was defined by the typical widening of the axon and the abrupt occurrence of a pool of SVs. The PreAZs and PSDs were regarded as complete when their perimeters ...

By comparing macaque and mouse PFC single-neuron projectomes, they revealed highly refined axon targeting and arborization in primates.

Further research highlights the essential role of microglia in synaptic pruning and neurodevelopmental processes, accentuating the importance of glia not only in support but also in cognitive and ...

In AD, synaptic plasticity, the brain's ability to regulate the strength of synaptic connections between neurons, is significantly disrupted.

At the synapse, neurons communicate chemically. When an action potential reaches the axon terminal, it triggers calcium influx, prompting vesicles to release neurotransmitters into the synaptic cleft.

This mechanism may also operate at other synapses. Strengths: The main strength of this study lies in combining patch-clamp recordings from axon terminals with imaging of presynaptic vesicular ...

Preserved axonal morphology and synaptic function in severed projections with dnmnat OE - mediated attenuated programmed axon degeneration We used a Drosophila model of impaired Wallerian degeneration ...

Monoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic ...

When the neurotransmitter binds to the neuron on the other side of the synaptic cleft, that post-synaptic neuron may change in some way.