Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

I like the promise of alternative pathway inhibition and believe Achillion’s factor D inhibitors could find their place in the complement space, but there is insufficient clinical evidence for ...

The disease is characterized by the deposition of C3 protein fragments in the filtering units (glomeruli) of the kidney, caused by overactivation of the complement alternative pathway (AP).

ARO-C3, an investigational RNA interference-based therapy targeting hepatic expression of complement component 3 (C3), was well-tolerated and demonstrated pharmacodynamic and clinical effects in ...

SARS-CoV-2 activates the alternative pathway through interactions with heparan sulfate. Plasma C5a levels were assessed with an ELISA in SARS-CoV-2 inoculated lepirudin-anticoagulated human blood ...

BCX9930, an Oral Factor D Inhibitor, Suppresses Complement Alternative Pathway C3 Convertase Activity in vitro, and in Patients with Complement 3 Glomerulopathy (Poster #80); Sunday, August 28 ...

BCX9930, an Oral Factor D Inhibitor, Suppresses Complement Alternative Pathway C3 Convertase Activity in vitro, and in Patients with Complement 3 Glomerulopathy (Poster #80); Sunday, August 28 ...