Topline results were released from the phase 3 MAPLE-HCM trial, which compared aficamten with metoprolol in 175 adults with ...

Their work reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also demonstrates the key role of gamma-actin in ...

Here, we used a standard gliding motility assay to study the actin filaments sliding on a surface comprising heavy mero myosin (HMM) micro- and nano-patterns. To print HMM, we used negative tone, ...

Trial Demonstrates Superiority of Aficamten to Standard of Care Beta Blocker in Improving Peak Exercise Capacity in Patients with Obstructive Hypertrophic Cardiomyopathy SOUTH SAN FRANCISCO, Calif.

These stripes occur due to alternating filaments that comprise myosin and actin proteins. The dark stripes indicate thick filaments that comprise myosin proteins, while the thin, lighter filaments ...

The iPhone 16 and Pixel 9 have undergone design changes compared to their predecessors, the iPhone 15 and Pixel 8. These changes are not significant, but they are noticeable nonetheless. The ...

Cells use the polymerization of actin alone to create some types of movement, but many other forms of movement require interplay between actin and an enzyme called myosin. Credit: extender_01 ...

Their findings challenge the classical dogma that the molecular motor myosin is essential for the ... of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed ...

Myosin-5 working stroke and walking on F-actin. (Credit: Klebl et al., 2024) The most amazing thing about cryo-EM is that it allows us to examine processes that used to be the subject of theory ...

We are studying the functions of molecular motors that exert directed force along actin filaments in mammalian cells. These motor molecules belong to the myosin superfamily. Different myosins show ...

The researchers designed an optogenetic tool to directly inactivate nonmuscle myosin II, which generates cellular contractility in coordination with actin filaments. To achieve this, they focused ...