Department of Biomedical and Molecular Sciences, Queen’s University, 18 Stuart Street, Kingston, ON K7L 3N6, Canada ...

The mechanical and structural properties of actin filaments play critical roles in various cellular functions, including structural support, cell movement, division, and intracellular transport.

Calcium signals cause calcium−calmodulin to activate CaMKII, which leads to remodeling of the actin filament (F-actin) network in the spine. We elucidate the mechanism of the remodeling by combining ...

Paxillin's function in regulating remodelling of the actin cytoskeleton is also discussed (Fig. 1). Figure 1: Integrin and growth-factor signalling through paxillin, and interactions with the ...

Redox signaling refers to the specific and usually reversible oxidation/reduction modification of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates several ...

In cardiac and skeletal muscles, myofilaments are key molecular regulators of the contraction. Indeed, thick-thin filament interactions (via the formation of myosin cross-bridges) lead to force ...