AZoLifeSciences on MSN2d
The Science of Antidotes: How Toxins Are Neutralized
Antidotes are critical in toxicology, offering therapeutic solutions to poisoning by neutralizing toxins and enhancing the ...
Nature4d
Ubiquitin-binding domains — from structures to functions
Ubiquitin-binding domains (UBDs ... including protein stability, receptor trafficking, DNA damage responses and inflammatory pathways. UBD preferences for distinct ubiquitin chains of specific ...
Nature4d
The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
‘…acute psychotic reactions, generally lasting but a few hours, but occasionally as long as a week; the reaction seemed dose-related and its main features ...
Frontiers4d
Dimensionality of Motion and Binding Valency Govern Receptor–Ligand Kinetics As Revealed by Agent-Based Modeling
We here consider the general problem of receptor–ligand binding in the context of antibody–antigen binding. On the one hand, we establish a quantitative mapping between macroscopic binding rates of a ...
Frontiers4d
Impact of structural modifications of IgG antibodies on effector functions
This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...