However, despite recent advances in glioblastoma (GBM), where intrathecal infusion of the IL13RA2/EGFRvIII dual targeting “OR gate” CAR-T is showing very encouraging signs of clinical activity (71) ...

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...

We analyze treatment scenarios inspired by clinical trials targeting IL13Rα2, HER2, and EGFRvIII antigens, comparing single-dose and cyclic dosing regimens. Our models incorporate key biological ...

A third teenager has been charged with the attempted murder of a 17-year-old boy in Hemlington. It comes following an alleged stabbing in Phoenix Park, in Hemlington, at 12.40am on Wednesday ...

The news: Shares in sports tech company Catapult soared on Wednesday on the back of higher full-year revenue and a reduced net loss. The numbers: Catapult, which makes wearables that enable data ...

In the case of glioblastoma (a type of brain tumor), specific targets such as B7H3 or EGFRvIII are being investigated. These antigens are only expressed on tumor cells, improving the accuracy of ...

Recently, CAR T-cell therapy specifically targeting EGFRvIII receptors of glioblastoma cells has been developed. Computer Aided Drug Design (CADD) has been an indispensable tool in the intricate drug ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. A novel optical approach for a noninvasive detection of mucins in tear fluid is ...

A stalker fitted a tracking device on a woman’s car to monitor her movements. Anthony White carried out a nine-month stalking campaign which involved tracking her vehicle and attending locations ...