San Francisco 49ers defensive back Deommodore Lenoir takes fans inside his biggest career moments in this episode of "Inside the Play" presented by Microsoft Surface Pro.

Kansas City asked a four-time All-Pro to move from guard to tackle, and he seeks to make history in more ways than one as he ...

Brock Purdy’s contract extension is the San Francisco 49ers’ new top offseason priority now that their defensive and special teams coordinator searches are over. While it would behoove San ...

The San Francisco 49ers went 6-10 in 2020 ... Defensive coordinator DeMeco Ryans is one of the greatest players in Texans history, as he led the defense at linebacker from 2006 through 2011.

The San Francisco 49ers continue to make sweeping changes across the coaching staff as they prepare to do the same with the roster as free agency and the NFL Draft approach. Special teams ...

Among them, experts expect Purdy to secure the most lucrative contract in 49ers history. However, the key question remains: where will his deal place among the NFL’s highest-paid quarterbacks?

Improving the offensive line will be one of the San Francisco 49ers' goals this offseason. The first step in doing so is dabbling in free agency. The 49ers usually don't go after talented free ...

View the video clips below to see the effects the Gold Rush had on the state of California and the country. Marcia Eymann visited the Center for Sacramento History and talked about the California ...

While the 49ers have tried to find the right player to rush the passer across from Nick Bosa, they've come up short. Additions like Leonard Floyd, Drake Jackson and Yetur Gross-Matos have shown ...

Immune checkpoint inhibitors, drugs that can help make the immune system recognize and destroy cancer more aggressively, are one of the most important medicines in cancer treatment today.

The San Francisco 49ers are in a good place financially entering a free agency where they'll have as many as 33 players entering some form of free agency. 24 of their FAs will be unrestricted ...