Opioid drugs and natural (or endogenous) opioids run along different paths inside neurons, which could explain why the “runner’s high” that results from exercise differs from the unnatural ...

Cite this: Preconditioning with anesthetics and endogenous opioids can protect against future ischemic insults - Medscape - Oct 17, 2003. Commenting is limited to medical professionals.

Opioid drugs produce their effects by binding to receptors in the endogenous opioid system, which the body uses to suppress pain and to reward biologically beneficial activities.

We can track endogenous opioid release in real-time, triggered by both reward and aversion and see the differences in opioid signaling in different brain circuits.” Dr. Tian’s team has already been ...

Endogenous opioids regulate moment-to-moment neuronal communication and excitability. Nature Communications, 2017; 8: 14611 DOI: 10.1038/ncomms14611 ...

Surprisingly, their brains released even more of the endogenous opioids after they ate a far less enticing—but nutritionally similar—liquid meal of what Nummenmaa called “nutritional goo.” ...

Source: Charles J. Sharp, via Wikimedia Commons. Distributed under a CC BY-SA 4.0 license. Riters and her team have begun exploring the role of endogenous opioids in the social play of rats.

People with depression show abnormalities in the body’s release of its own, endogenous, opioid chemicals. Depression tends to exacerbate pain—it makes chronic pain last longer and hurts the ...

The opioid receptor antagonist naltrexone (NTX) is one of few approved treatments for alcoholism, yet the mechanism by which it reduces drinking remains unclear. In rats, NTX reduces morphine ...

A clinical trial of an experimental drug for treatment-resistant major depression finds that modulation of the endogenous opioid system may improve the effectiveness of drugs that target the action of ...