Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

They suggest p97 acts downstream in the SUMO-ubiquitin pathway, potentially helping mop up aberrant misfolded TDP-43. Their conclusion? Hauling TDP-43 into nuclear bodies initiates SUMOylation and ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in ...

The Phase I segment involves a dose escalation study of the therapy as a single agent and in conjunction with oral ...

When the cellular waste disposal system goes on strike, this can have fatal consequences. A research team at the University ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent ...

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its ...