Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in ...

The Phase I segment involves a dose escalation study of the therapy as a single agent and in conjunction with oral ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent ...

MYLIP relies on its enzymatic activity to target HIF-α, triggering K27-linked polyubiquitination and subsequent proteasomal degradation, thereby suppressing the hypoxic signaling pathway and ...

Before the development of α-synuclein immunohistochemistry, ubiquitin staining was routinely ... 3 illustrates how these pathways might fit together. Now that these different mechanisms have ...

A fundamental, conserved repulsive signaling pathway is initiated by the Slit-Robo ligand-receptor ... PY motifs have been shown to bind WW-domain containing proteins including the ubiquitin ligase ...

In this study we have used extensive experimental NMR data, in combination with statistical coil ensemble modeling and small-angle scattering, to analyze the conformational behavior of the protein ...