Using a new animal model of Alzheimer’s disease, the study highlights a potential breakthrough in treatment strategies.

A model for hepatitis B virus-associated chronic ... Figure 2: Concentration of HBV DNA in the sera of transgenic mice. Figure 3: Detection of viral antigens in the serum and liver of transgenic ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the ...

A new study published in Brain, Behavior, and Immunity has found that inflammation in a key memory center of the brain can change motivated behavior in mice, and these changes occur differently in ...

Creating transgenic rodent models requires transgenesis: the introduction of exogenous DNA sequences into the genome, typically to drive protein expression in a specific spatial or temporal way.

To do so, they developed a transgenic mouse model carrying a slime mold endonuclease that, when treated with the drug tamoxifen, induces in the animal’s genome, triggering DNA repair and the resulting ...

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...

2025). While this phenomenon has not yet been demonstrated in APP A7 transgenic, users of this model should be aware of the findings in 5xFAD mice when designing and documenting breeding strategies.

Transgenic animals serve as valuable models for studying human diseases and testing new therapies. For instance, transgenic mice expressing human disease-related genes have been used to investigate ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the ...