The monoamine hypothesis of depression postulates a deficiency in serotonin or norepinephrine neurotransmission in the brain. Monoaminergic neurotransmission is mediated by serotonin (5 ...

Recently, Moncrieff and colleagues published a review of the evidence for the serotonin theory of depression, concluding that there was “no consistent evidence of there being an association ...

To understand why the histamine connection is novel, you have to know the two classical hypotheses of depression: the monoamine hypothesis and the cytokine hypothesis. (These are eloquently ...

"Dominant now is the monoamine hypothesis of antidepressant function, which was originally formulated in the 1960s and 1970s. It states that depression is the result of a chemical imbalance of ...

However, with recent findings essentially dethroning the monoamine theory of depression, kynurenine might soon have its day in the funding sun. To be fair, it’s possible that numerous anti-depression ...

Sequestered prion protein takes the good mood away, suggests new hypothesis on depression. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2015 / 08 / 150813104308.htm ...

Despite the replacement of the monoamine hypothesis of depression with a more comprehensive understanding of multiple influencing factors in the pathology of depression, it is clear that elevating ...

The ‘monoamine hypothesis’ of depression, which involves imbalances in serotonergic, noradrenergic and possibly dopaminergic functions, has dominated notions and explanations of the ...