These specialized, ECM attachment organelles and signalling centres are called focal complexes when they are still nascent and in the process of forming, or focal adhesions (FAs ... Figure 2. Talin ...

Here we identify an antigen‐triggered mechanism that actively promotes T‐cell synapse symmetry by generating cytoskeletal tension in the plane of the synapse through focal nucleation ... post‐initial ...

In motile cells, sites of adhesion within filopodia and lamellipodia are relatively small and transient and are referred to as ‘focal complexes,’ whereas adhesions underlying the body of the ...

This review focuses on the focal-adhesion adaptor protein paxillin, and discusses the role that it, and its many binding partners, play in transduction of adhesion and growth-factor signals at the ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18 ...

Mayor Ras Baraka of Newark staged a predawn demonstration outside an immigrant detention center. He argues that the facility’s owner does not have valid permits to operate. By Tracey Tully and ...

"Youth of the West Bank, youth of Jerusalem, and those inside Israel, set their cars ablaze... Gaza awaits the revenge of the free," the terrorist organization wrote ...

J-pouch surgery can successfully relieve symptoms of ulcerative colitis if medications and other treatments haven’t worked, but complications may arise. Depending on the type of irritable bowel ...

Generalised tonic-clonic seizures are hard to miss. But this is not what most epileptic seizures look like. Focal onset seizures Most epileptic seizures in people with dementia are known as focal ...

Here, we report that nanotopography-induced human mesenchymal stem cell (hMSC) differentiation through cell mechanotransduction is modulated by the integrin-activated focal adhesion kinase (FAK). On ...

That's because different focal lengths (offering different fields of view) result in unique views of a scene, allowing you to create dramatically different images based on which lens you select.