The move drew sharp criticism from medical and health experts. “Scrapping the fastest platform we have is a reckless move ...

In cotransfection experiments with SC35 and an AChE minigene, SC35 shifted alternative splicing towards the stress-associated variant, AChE-R mRNA.

HNF1A mutations are found to dysregulate RNA splicing in pancreatic cells, thereby contributing to the onset of diabetes.

They found similar splicing changes in 52 of the 84 genes, with a similarly strong association with AD as in the ROS/MAP cohorts. What drives these splicing changes? One clue came from an in vitro ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production ...

Serine/arginine-rich splicing factor 3 (SRSF3), a member of the serine/arginine (SR)-rich family of proteins, regulates both alternative splicing of pre-mRNA and export of mature mRNA from the ...

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization might affect the splicing process. In a recent article, he showed that ...

This project aims to develop mRNA anti-cancer vaccines based on shared frequently misspliced aberrations and test whether these are enhanced in combination with other therapies. Project aims Aim 1: ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...

Xue-Cheng Zhang, Walter Gassmann, Alternative Splicing and mRNA Levels of the Disease Resistance Gene RPS4 Are Induced during Defense Responses, Plant Physiology, Vol. 145, No. 4 (Dec., 2007), pp.