Pre-mRNA splicing is a fundamental step in mRNA maturation and its discovery in 1977 revolutionized our understanding of gene expression. This collection includes reviews and research articles ...

mRNA splicing regulation as an essential factor in osteoclast differentiation. (IMAGE) Tokyo University of Science ...

They found similar splicing changes in 52 of the 84 genes, with a similarly strong association with AD as in the ROS/MAP cohorts. What drives these splicing changes? One clue came from an in vitro ...

Xue-Cheng Zhang, Walter Gassmann, Alternative Splicing and mRNA Levels of the Disease Resistance Gene RPS4 Are Induced during Defense Responses, Plant Physiology, Vol. 145, No. 4 (Dec., 2007), pp.

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization might affect the splicing process. In a recent article, he showed that ...

To take advantage of cancer cells’ splicing errors, the scientists developed mRNA molecules with lab-designed introns that can only be spliced — and then translated into protein — by cells with ...

This project aims to develop mRNA anti-cancer vaccines based on shared frequently misspliced aberrations and test whether these are enhanced in combination with other therapies. Project aims Aim 1: ...

All cells in the body rely on the same set of approximately 25,000 genes as the blueprint for the proteins they need to carry out their activities. They expand this limited repertoire through a ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

Splicing and transcription touch base: co-transcriptional spliceosome assembly and function Pre-mRNA splicing occurs on nascent RNA, which is attached to chromatin by RNA polymerase II.