The typical presentation of patients with Liddle syndrome includes early-onset severe hypertension, hypokalemia, metabolic alkalosis in the setting of low plasma renin and aldosterone, low rates ...

Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, ...

The observed treatment rates, which “absolutely can go higher,” wouldn’t be acceptable for serious cancers, Stephen Greene ...

Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, ...

Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, can improve survival rates in patients 90 years of age and older following ...

The addition of SGLT2i to RAASi was associated with lower hyperkalemia risk among patients with diabetes, heart failure, or CKD.

Higher serum sodium levels, even within the normal range, are linked to increased risk of developing hypertension and heart ...

46 Adrenal (fatigue, hypotension) 8:00 AM ACTH, 6-8:00 AM cortisol Hydrocortisone 10 mg every morning, 5 mg every evening Hydrocortisone 50 mg once every 6 hours Hypophysitis (fatigue, headache, ...

Cigarette smoking poses a significant threat to kidney health, increasing the risk of chronic kidney disease and accelerating ...

The renin system evolved when cartilaginous fish began to develop bone >500 million years ago, preceding any contribution of angiotensin to BP and angiotensin-dependent aldosterone release. 26 At that ...

HFrEF is characterised by the overactivation of the neurohormonal axis—particularly of the sympathetic nervous system and the renin–angiotensin–aldosterone system. Initially this is an adaptive ...

Lorundrostat, a novel therapy which blocks the production of aldosterone from the adrenal glands, demonstrated clinically meaningful and sustained reductions in blood pressure in 1,083 patients ...