This study reports important negative results by showing that genetic removal of the RNA-binding protein PTBP1 in astrocytes is not sufficient to induce their conversion into neurons, challenging ...

We present a general framework for studying intrinsic fluctuations in gene expression that arise from RNA post-transcriptional splicing. In particular, we decompose the coefficient of variation for ...

The researchers created a novel mouse model of RNA splicing defects called N40K-Tg. The scientists observed basic neurodegeneration when they deregulated the splicing machinery, but they wanted to ...

Instead, the model's accuracy shows that, with the new data from the lariats, scientists have gained a more general understanding of how the body chooses among alternative splicing sites.

BigRNA is the first foundation model for RNA that has been shown to be effective for a range of drug discovery tasks, including predicting the effects of patient variants on RNA processing mechanisms, ...

Learning the Sequence Determinants of Alternative Splicing from Millions of Random Sequences. Cell, October 2015 DOI: 10.1016/j.cell.2015.09.054 ...

Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA. Previous studies have demonstrated an ...