News

eLife6d
Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers
This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption of its interaction with RXRg, similar to the family member ...
Nature2d
Synthesis of thermoresponsive unimolecular polymeric micelles with a hydrophilic hyperbranched poly(glycidol) core
Up to now, water-soluble hyperbranched poly(glycidol) (HPG) has been used widely to prepare amphiphilic molecular nanocapsules because it is highly biocompatible and ...
C&EN6d
Synthesis of the Hydrazinyl Pyridine Intermediate: Phase-Appropriate Delivery
† Process Development, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States ‡ Process Development, Amgen Inc., One Amgen Drive, Thousand Oaks, California 91320, United States ...
C&EN3d
Novel Thiazolidinedione and Rhodanine Derivatives Regulate Glucose Metabolism, Improve Insulin Sensitivity, and Activate the Peroxisome Proliferator-Activated γ Receptor
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. No ...