No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

"Our work will have a huge impact on mRNA and RNAi-based therapies and drug ... we can restore tumor suppressor gene ...

Scientists at the University of California, Irvine, have discovered that nuclear speckles, a membraneless organelle within ...

D.P. Lane, S. Benchimol, "p53: Oncogene or anti-oncogene?" Genes & Development, 4:1-8, 1990. David Lane (Cancer Research Campaign Laboratories, University of Dundee, Scotland): "Cancer is a multistep ...