p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53. “Altogether, we’ve identified a cellular circuit capable of ...