By leaving cyclo-oxygenase 1 (COX1)-mediated platelet aggregation and gastric protection unopposed, drugs selectively blocking the COX2 isoenzyme promised similar pain control and fewer ...

Researchers show that cordycepin, a compound from Cordyceps militaris, can boost endurance and protect brain function in mice ...

Other types of DNA methylation have been normally perceived to be toxic. In Escherichia coli the 2OG oxygenase AlkB catalyzes repair of N-alkylated single-stranded DNA caused by alkylating agents 15.

The pioneering work by Widboom et al. 3 provides a picture of a cofactor-independent oxygenase with both the substrate and molecular oxygen bound in a catalytically relevant orientation ...

Neben seiner Facharztausbildung in Herzchirurgie und dem Zusatzfach Gefäßchirurgie erwarb er einen PhD in Gefäßbiologie mit einer Arbeit zum Thema „Effect of Heme Oxygenase-1 Induction on ...

health.wa.gov.au There has been a great deal written about the use of selective cyclo-oxygenase-2 (COX-2) inhibitors in the adult population. Yet despite this there is still controversy over their ...

3 Diclofenac is thought to exert its action by reducing prostaglandin synthesis through inhibition of the cyclo-oxygenase enzymes (COX-1 and COX-2). It is classified as a non-selective COX inhibitor, ...

Induction of heme oxygenase (HO-1) by reactive oxygen species is a general cytoprotective mechanism against oxidative stress. HO-1 catabolises heme to bilirubin, free iron and carbon monoxide (CO).

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan School of Life Sciences and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road ...

Non-steroidal anti-inflammatory drugs (NSAIDs) and traditional disease modifying antirheumatic drugs (DMARDs) are widely used in the treatment of psoriatic arthritis (PsA), but this is based more upon ...