Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity Kathleen M Knights; Arduino A Mangoni; John O Miners Disclosures Expert Rev Clin Pharmacol. 2010;3 (6):769 ...

The increased risk for ibuprofen was 24% and for the now withdrawn selective COX-2 inhibitor rofecoxib was 32% (both p < 0.05). [22] ...

They searched for randomized controlled trials comparing the risk of GI adverse effects in patients taking nonselective NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, or nonselective NSAIDs ...

NSAIDs stop proteins called cyclooxygenase, known as COX, and fall into two classes: “selective” COX-2 inhibitors (celecoxib, etoricoxib, or rofecoxib) and “nonselective” COX-1/COX-2 ...

Traditional NSAIDs -- like aspirin or ibuprofen -- block the action of both COX-1 and COX-2, which is why some people suffer from stomach upset after taking them, the AAOS said.

COX-2 inhibitors, also known as selective COX-2 inhibitors, are nonsteroidal anti-inflammatory drugs (NSAIDs) that treat inflammatory pain. They’re available by prescription and may be easier on ...

The use of COX-2 selective inhibitors reduces the risk of upper gastrointestinal clinical events, compared with NSAIDs, in patients taking PPIs or low-dose aspirin; however, this result was driven ...

As a result, efforts were undertaken to create NSAID painkillers that blocked COX-2 but left COX-1 unaffected, products termed selective COX-2 inhibitors.

12. Cox ER, Frisse M, Behm A, Fairman KA. Over-the-counter pain reliever andaspirin use within a sample of long-term cyclooxygenase 2 users. 2004 Jun 14;164 (11):1243-1246. N Engl J Med. 13.

Well, COX-2 inhibitors are NSAIDs, but they're newer NSAIDs that were developed to avoid some of the stomach problems that the older NSAIDs caused.<p>So, NSAIDs increase the risk of stomach ulcers ...