Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

Notably, SIRT1 functions as a sensor of redox changes and plays a critical protective role against ferroptosis by regulating redox homeostasis via Nuclear factor erythroid 2-related factor 2 (Nrf2) ...

Conversely, treatment with RSV activated the NRF2 pathway and mitigated the oxidative stress in ... Protein levels of cleaved-caspase-3 and p53, along with the TUNEL assay, provided no significant ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

This important study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor KEAP1, leading to cytoprotective gene ...

1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. 2Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, China. 7Suzhou Biomedical ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...