Pharmacology of NSAIDs NSAIDs act by inhibiting cyclooxygenase, an enzyme involved in the formation of various prostanoids with a wide variety of pharmacologic actions. 11 The COX-2 selective NSAIDs ...

Although there are minor differences in the mechanism of action of NSAIDs, they are all inhibitors of the cyclo-oxygenase enzyme (COX); thus, they prevent the conversion of arachidonic acid into ...

Surprisingly, the researchers found that NSAIDs exacerbate C. difficile infection independent of COX inhibition and instead through off-target effects on mitochondria. They did so by treating colonic ...

NSAIDs (non-steroidal anti-inflammatory drugs), such as aspirin, inhibit cyclooxygenase enzymes (COX-1 and COX-2) that catalyze formation of prostaglandins from arachidonic acid and they have been ...

Cite this: Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity - Medscape - Nov 01, 2010.

Koo noted that since many researchers and clinicians have proposed that NSAIDs are effective in Alzheimer’s disease by inhibiting COX enzymes and therefore inflammation, the UCSD/Mayo team ...