A U of A researcher recently created a new class of drugs that targets and kills cancer cells with less damage to healthy ...

NMT is thought to play a key role in various ... according to Myricx, its inhibitors have been shown to regress tumours in solid tumours that do not respond well to current payloads like tubulin ...

Zelenirstat is a pan-NMT inhibitor that leads to multiple mechanisms of AML cell death. The newly launched trial has 2 parts; in the dose escalation portion, a maximum of 15 patients will be enrolled ...

Prof. Ed Tate delivered a keynote lecture, reflecting on a two-decade-long project in the Tate group—the development and translation of NMT inhibitors—culminating in over £100 million in investment ...

Since malonyl-CoA is an allosteric inhibitor of CPT1, AMPK promotes fatty acid β-oxidation ... with Gly2 sites on both β1 and β2 subunits being myristoylated by N-myristoyltransferase (NMT). Research ...

Calcineurin inhibitors are topical and systemic immunosuppressants. They can help treat atopic dermatitis and autoimmune disorders such as lupus and psoriasis. They may also help prevent organ ...

The ADC payload landscape is shifting rapidly. Driven by clinical successes of lower potency topoisomerase I inhibitors and as payloads that elicit novel modes of action continue to gain momentum ...

Which of the statements about the diagnosis and management of difficult-to-treat rheumatoid arthritis are correct?