C2C12 cell culture, transfection of luciferases and overexpression ... higher than controls, p=0.006: figure 2). Neither myostatin, insulin-like growth factor-1 (IGF-1) or Muscle Ring Finger-1 (MuRF-1 ...

And down the line the discovery of that myostatin protein gene, could play a role in developing a weight loss drug that preserves muscle while getting rid of fat. The value in the discovery is ...

Nearly 30 years later Dr. Se-Jin Lee's discovery of myostatin is not only leading to treatment for spinal muscular atrophy but also fueling the global obesity drug research race Dr. Se-Jin Lee and Dr.

Myostatin-ActRIIB-ALK5-Smad2/3 is another signaling pathway that finally combines to Smad4 to cause protein degradation in skeletal muscle. Sestrin2 can activate the Sestrin2-Keap1-Nrf2 pathway, ...

Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some common botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial ...