Non-muscle myosin II (NM II) is a hexameric actin-binding protein that is formed of two heavy chains, two essential light chains and two regulatory light chains. Its conformation and function are ...

No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...

Topline results were released from the phase 3 MAPLE-HCM trial, which compared aficamten with metoprolol in 175 adults with ...

A new study shows the tradeoff between power and efficiency in muscles is governed by proteins that form a molecular tuning ...

Most importantly, the drug omecamtiv rescues the processivity of the mutant by slowing down the actin-independent phosphate release from Myosin VI. Thus, we also explore the molecular mechanism behind ...

Golgi morphology and function are dependent on an intact microtubule and actin cytoskeleton. Myosin VI, an unusual actin‐based motor protein moving towards the minus ends of actin filaments, has been ...

Important downstream targets include myosin II motors, actin capping and severing proteins, formins, profilin, cofilin, and the actin-related protein-2/3 complex. Actin filament remodeling, focal ...

The findings presented in this manuscript are fundamental, as they uncover MYL3, a member of the myosin family, as a potential entry ... X-100 or not and immunostained with anti-Myc abs or anti-Actin ...

New research from the Sainsbury Laboratory at the University of Cambridge has shed light on how plants precisely control ...

Two New Analyses from SEQUOIA-HCM on Effect of Aficamten Between Patientswith Mild and Moderate-to-Severe Symptoms, and ...

Trial Demonstrates Superiority of Aficamten to Standard of Care Beta Blocker in Improving Peak Exercise Capacity in Patients with Obstructive Hypertrophic Cardiomyopathy The full results from ...

One of the key benefits of acupuncture for any athlete, high-impact especially, is its ability to enhance performance.