Alphamab Oncology (stock code: 9966.HK) announced that the Investigational New Drug (IND) application for JSKN022, an independently developed innovative bispecific antibody-drug conjugate (ADC) ...

Lysosome Targeted Nanoparticle Aggregation Reverses Immunosuppressive Tumor Microenvironment for Cancer Immunotherapy Journal: Advanced Materials Published: 2024-11-01 DOI: 10.1002/adma.202412730 ...

Alphamab Oncology (stock code: 9966.HK) announced that the Investigational New Drug (IND) application for JSKN022, an independently developed innovative bispecific antibody-drug conjugate (ADC) ...

"Lysosomes are organelles that are involved in autophagy, a cellular process that cleans up damaged material, almost like a housekeeping or recycling system," said Tan.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

By detecting lipid oxidation, the research team found that lipid oxidation in lysosomes is the cause of ferroptosis, iron mediated cell death. This results to leakage of iron from lysosomes which ...

As such, they are also relevant for the development and growth of cancer. Hirao and colleagues first checked whether lysosome activity is an indicator of glioblastoma progression.

There is no cure for glioblastoma; treatments can slow cancer growth and reduce symptoms. Lysosome Lysosomes are organelles, enclosed by membranes, located within cells.

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for ...