The suitability of a recombinant virus for liver gene transfer is based on several factors, including the infectious titer that can be achieved, the ability of the virus to infect nondividing cells, ...

Pushmi-pullyu Of B-cell Development Discovered Date: June 26, 2009 Source: National Jewish Medical and Research Center Summary: Scientists have identified two "molecular motors" that work in ...

RNA exosome key for B cell development Findings explain immunodeficiency in rare syndrome and could offer new ways to treat autoimmune diseases Date: June 13, 2022 Source: UT Southwestern Medical ...

When they inactivated Mi-2/NuRD instead, expression of the B-cell gene increased 1,727-fold. Mi-2/NuRD was apparently acting as a brake, and its removal vastly increased expression of the B-cell gene.

B cells originate in fetal liver and bone marrow in mammals, developing from hematopoietic stem cells (HSCs). HSCs become multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP ...

This in vitro model, with its varied cell composition and biomimetic structure, serves as a valuable resource for liver disease research, drug development, and regenerative medicine studies.

A comprehensive map of human B cell development has been created by a team of researchers. Their approach will greatly improve researchers' ability to investigate development in cells of all types.

Blocking a key metabolic enzyme helps B cells fight liver tumors, revealing a new immunotherapy pathway for fatty liver–driven cancer in mice.

Stem cell research and therapy for liver and kidney diseases is a rapidly evolving field with significant therapeutic ...

Research Highlight Published: November 2007 B-Cell Development (micro)Control of B-cell development Olive Leavy Nature Reviews Immunology 7, 835 (2007) Cite this article ...

A new paper in the May 15th issue of Genes & Development reveals how a protein called Yin Yang 1 regulates early B cell development. B cells are the antibody-producing cells of the body, which ...

The epidemic of obesity worldwide has increased the risk of accumulating fat in the liver, a preamble to liver inflammation and liver disease. Yet, a still intriguing paradox is the development of ...