Defibrotide prophylaxis after HSCT did not reduce sinusoidal obstructive syndrome incidence in high-risk pediatric patients, per retrospective study at 2025 Tandem Meeting.

Massive infiltration of liver sinusoids by lymphoma cells (Figure 1) and NRH (Figures 1 and 2) was confirmed. The patient was therefore diagnosed with primary splenic lymphoma and hepatic ...

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal ... abundant cell type in liver, are a potent source ...

Rerouting of portal blood to the sinusoids was accomplished by excision of the involved liver in the right lobe and by occlusion of the left branch of the portal vein. This was accompanied by an ...

Repair of liver injury is initiated by interactions between injured hepatocytes and liver sinusoidal endothelial cells (LSEC), however, chronic injury can lead to fibrosis. Here, using a ...

Objective Vascular remodelling during liver damage involves loss of healthy liver sinusoidal endothelial cell (LSEC) phenotype via capillarisation. Hedgehog (Hh) signalling regulates vascular ...

referred to as liver zonation, along which hepatocyte and sinusoidal function varies. The portal triads consist of mesenchymal cells surrounding the portal vein (PV), hepatic artery (HA), and the ...

These include reduction in portal pressure, improved liver sinusoidal endothelial and hepatic microvascular dysfunction, decreased fibrogenesis, protection against ischaemia/reperfusion injury, safe ...

The liver, located in the upper right side of the abdomen, is the body’s largest organ and one of the most important. The liver performs hundreds of vital functions, including converting ...

What Does Liver Pain Feel Like? Your liver is a football-sized organ that sits under your ribs. It filters and cleans your blood, stockpiles energy, helps you fight infections and diseases ...