Dávid Héja, Andrea Kocsis, József Dobó, Katalin Szilágyi, Róbert Szász, Péter Závodszky, Gábor Pál, Péter Gál, Revised mechanism of complement lectin-pathway activation revealing the role of serine ...

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

In addition to its lectin pathway inhibitors, the company is advancing its development of antibodies and small-molecule inhibitors against MASP-3 to block activation of the alternative pathway.

Rune T. Kidmose, Nick S. Laursen, József Dobó, Troels R. Kjaer, Sofia Sirotkina, Laure Yatime, Lars Sottrup-Jensen, Steffen Thiel, Péter Gál, Gregers R. Andersen, Structural basis for activation of ...

OMS721 is Omeros’ lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of the complement system.

The panel discussed the emerging evidence that endothelial injury and the activation of the lectin pathway of complement are central drivers of the acute respiratory distress syndrome (ARDS) and ...