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Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Science, 2024; 385 (6708) DOI: 10.1126/science.adk5901 Qing He, Feng Wang, Michael E. O’Donnell, Huilin Li.
A DNA helicase, powered by ATP hydrolysis, propels itself rapidly along one of the template DNA strands (here the lagging strand), forcing open the DNA helix ahead of the replication fork.
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