The results suggest a two-step model for focal adhesion assembly. “We show that integrin activation comprises two steps: first, phosphorylation of Cas and its recruitment to inactive integrin, which ...

More information: Wei-Wei Ren et al, MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202407068 ...

Contrary to what the terms cytoskeleton and focal adhesion suggest, these anchoring points are by no means static. During the movement of cells, for example, they are constantly dissolved and ...

Background: PDAC is an aggressive cancer. It remains refractory to checkpoint inhibition because of its significant desmoplastic and immunosuppressive tumor microenvironment (TME). Focal adhesion ...