The fibrous proteins and ground substance produced by fibroblasts are what constitute the extracellular matrix (ECM), which makes up the bulk of connective tissue. The ECM has many roles within ...

University researchers have developed a new connective tissue model to study disorders like fibrosis, a type of scarring that occurs when damage to the body causes normal tissue to be replaced by hard ...

Fibroblasts play a central role in maintaining healthy tissue structures, as well as in the development and progression of diseases. For a long time, these specialised connective tissue cells were ...

These CD201+ progenitors give rise to different types of fibroblasts, and two regulatory gates are needed for the wound healing phases to move along at the right time.

In this new development, researchers reprogrammed ordinary connective tissue cells called fibroblasts, taken from mice, directly into the desired lung cells, completely bypassing the need for stem ...

Lennart Franzén, Claes Dahlquist, The Effect of Transforming Growth Factor-β on Fibroblast Cell Proliferation in Intact Connective Tissue in vitro, In Vitro Cellular & Developmental Biology. Animal, ...

Resting fibroblasts are important, however, for maintaining the structure and functioning of healthy tissue. Researchers therefore studied the differences between the surfaces of resting and of ...

Tissue engineers are working on a variety of proj-ects. Here are just a few candidates for future human replacement parts. Skin: Chemical engineers agree that skin will be the first engineered tissue ...

Shattuck Lecture Archive The Fibroblast — A Ubiquitous Ally for the Surgeon Author: J. Englebert Dunphy, M.D. Author Info & Affiliations Published June 20, 1963 N Engl J Med 1963;268: 1367 - 1377 ...

Connective tissue is produced in part by fibroblast cells. Early evidence The findings build on earlier research from d'Azzo's laboratory. That work centered on mice that lacked the Neu1 gene.

Conversely, fibroblasts sometimes undergo mesenchymal–epithelial transition (MET) to produce epithelia. This process is seen as part of normal development, tissue repair and tumor growth.