The gut microbiome and the metabolites it produces offer promising insight into disease severity in critically ill patients.

Find more information on the Altmetric Attention Score and how the score is calculated. The human apical sodium-dependent bile acid transporter (hASBT) may serve as a prodrug target for oral drug ...

Understanding how the gut microbiota modulates bile acids and signalling through FXR to modulate host metabolism may provide novel insights into how the microbiota can be targeted to prevent obesity.

1 Section of Pediatric Critical Care, Baylor College of Medicine, Houston, Texas, USA 2 Department of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas, USA Correspondence to Dr ...

Medications in this group include peroxisome proliferator-activator receptor agonists (eg, pioglitazone, elafibranor, saroglitazar), medications targeting the bile acid-farnesoid X receptor axis ...

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China ...

Figure 1: Steady-state mRNA levels of genes that are regulated by Tcf1. Figure 4: Bile acid concentrations are increased in the serum, stool and urine of Tcf1 −/− mice. Figure 5: Tcf1 is a ...

These findings suggest that ZJW exerts its therapeutic benefits by activating FXR, modulating bile acid metabolism, and reshaping the gut microbiota. Current research suggests that BA metabolism and ...

The Farnesoid X receptor (FXR) serves as the central regulatory node for bile acid sensing, exhibiting ligand-dependent activation kinetics with distinct activation thresholds for different bile acids ...