News Medical on MSN8d
FXR cyclic peptide antagonists as a novel strategy for MASH treatment
In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...
News Medical9d
Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH
The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...
News Medical28d
Exploring the link between cholestasis and depression
highlighting the key roles of bile acid receptors, such as FXR and TGR5, in this process. Additionally, the gut-brain axis has been shown to be involved in the development of brain diseases in a ...
Armed robbery in Revesby8d
FXR Peptide Antagonists: New Strategy for MASH Treatment
The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...
Medscape20d
The Vitamin D–antimicrobial Peptide Pathway and Its Role in Protection against Infection
It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...
The EMBO Journal2d
Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury
Primary BAs, i.e., cholic acid (CA) and chenodeoxycholic acid (CDCA), are synthesized ... These effects are mediated through the activation of nuclear receptors, such as farnesoid X receptor (FXR) and ...
pharmaphorum2d
Court sides with EU on decision to revoke Ocaliva's license
The European Commission revoked the conditional marketing authorisation for Ocaliva (obeticholic acid) earlier this year ... allowing the FXR agonist to remain on sale, but the company confirmed ...