The EMBO Journal2d
Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury
Primary BAs, i.e., cholic acid (CA) and chenodeoxycholic acid (CDCA), are synthesized ... These effects are mediated through the activation of nuclear receptors, such as farnesoid X receptor (FXR) and ...
pharmaphorum2d
Court sides with EU on decision to revoke Ocaliva's license
The European Commission revoked the conditional marketing authorisation for Ocaliva (obeticholic acid) earlier this year ... allowing the FXR agonist to remain on sale, but the company confirmed ...
pharmaphorum2d
Advanz Pharma's bid to keep Ocaliva on EU market fails
said that Ocaliva is the only FXR agonist for patients with PBC, and until now the only approved and available second-line treatment option in Europe after ursodeoxycholic acid (UDCA). Advanz ...
gut.bmj5d
Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
Objective Bile acids are important regulators of intestinal physiology, and the nuclear bile acid receptor, farnesoid X receptor (FXR), is emerging as a promising therapeutic target for several ...
Naturopathic Doctor News and Review1d
Gut Bacteria Convert Bile Acids to Heal Intestines in Colitis and Crohn’s
New research reveals that specialized gut bacteria convert bile acids into powerful healing compounds, offering hope for ...
Frontiers6d
Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data
Background: The tumor microenvironment (TME) plays a critical role in the development, progression, and clinical outcomes of hepatocellular carcinoma (HCC). Despite the critical role of natural killer ...