In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

They do all this by binding to a receptor called FXR, which acts like a traffic light, controlling cholesterol metabolism and bile acid production to avoid excess buildup." Here's where the ...

It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...

The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health. When this microbial balance is disturbed, it can contribute to the development of ...

FXR helps regulate several important processes in the body, such as metabolism and production of bile acid. By Ocaliva’s mechanism of action, FXR reduces how much bile is made from cholesterol.

highlighting the key roles of bile acid receptors, such as FXR and TGR5, in this process. Additionally, the gut-brain axis has been shown to be involved in the development of brain diseases in a ...