"We discovered that abnormal tau proteins accumulate in retinal ganglion cells, which are key nerve cells in the eye that send information to the brain," said Maya Koronyo-Hamaoui, Ph.D ...

and block fluid from draining out of the eyes. This in turn increases eye pressure and can cause damage to the optic nerve.

The hypothesis that it disrupts the function of retinal ganglion cell axons by increasing mechanical forces on the lamina cribrosa of the optic nerve head has received considerable experimental ...