It is also defined as cell death accompanied by caspase activation. The major signaling pathways that trigger apoptotic cell death are the mitochondrial (the intrinsic) pathway and the death receptor ...

In the intrinsic pathway cellular stress, once detected, causes the cell to self-initiate apoptosis. In the extrinsic pathway, apoptosis is initiated by external signals from other cells.

In extrinsic and intrinsic apoptosis, this destruction induces the formation of apoptotic bodies through blebbing of the plasma membrane into smaller vesicles. These vesicles contain the dying cell’s ...

Two pathways of apoptosis have been identified, the extrinsic and the intrinsic. The former is mediated by the activation of death ligands (FasL, TNF) on their interaction with their respective ...