It has long been thought that two enzymes, the kinases CDC7 and CDK2, are both needed to trigger DNA replication in mammalian cells. This view is challenged by evidence that offers a revised view ...

At no time is the DNA more vulnerable than when it is being copied during cell division so that it can be shared between descendent cells. To avoid mistakes during DNA replication, cells use ...

"Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs." ScienceDaily. ScienceDaily, 9 August 2018. <www.sciencedaily.com / releases / 2018 / 08 / 180809112516.htm>.

In addition to DNA polymerase, DNA replication also requires several other enzymes including a helicase to unwind the double-stranded template DNA, as well as a primase to assemble a short RNA primer.

“These results strongly suggest that these mutations occur as APOBEC3G attacks cytosines during DNA replication, while they're most exposed on the lagging strand template,” Dr. Foster said.

"Enzymes could be key to understanding how DNA mutates, quantum biologists find." ScienceDaily. ScienceDaily, 16 November 2022. <www.sciencedaily.com / releases / 2022 / 11 / 221116085938.htm>.

The first step in replication is an enzyme called helicase that unwinds and “unzips” the double helix into two single strands. An enzyme called primase attaches a “primer” to each strand that allows ...

The DNA polymerase delta enzyme selects the right bases, and proofreads the sequences formed, as well as helping to repair the rare errors. The enzyme is composed of a core made up of p125 and P50 ...

Researchers at the University of Toronto’s Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from ...

An INRS team discovers a new family of enzymes capable of inducing targeted cuts in single-stranded DNA A few years ago, the advent of technology known as CRISPR was a major breakthrough in the ...