The “lock and key” model was first proposed in 1894. In this model, an enzyme’s active site is a specific shape, and only the substrate will fit into it, like a lock and key.

Enzymes are vital to metabolism and drive countless biological processes in humans, plants, and industry. Yet, when ...

Weizmann Institute of Science-led researchers have unveiled a computational workflow that crafts enzymes exhibiting catalytic efficiencies surpassing 100,000 M−1 s−1, achieving performance comparable ...

R. Rogers Yocum, David J. Waxman, James R. Rasmussen, Jack L. Strominger, Mechanism of Penicillin Action: Penicillin and Substrate Bind Covalently to the Same Active Site Serine in Two Bacterial ...