Causes: LIG4 syndrome is caused by a mutation in the LIG4 gene, which carries the instructions needed to make a protein known as DNA ligase 4. This protein is an enzyme that helps repair a ...
However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.
The applied physicist explains how the structure of 52,000-year-old genes hint at the biology of an extinct animal ...
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
The recent approvals and robust pipeline activity are expected to fuel the market of molecular glues in the 7MM during the forecast period 2025-2034 due to factors like improved diagnosis, treatment ...
UBE3A is an E3 ubiquitin ligase encoded by an imprinted gene whose maternal deletion ... levels in human neuronal cell culture models revealing significant effects on DNA methylation leading to ...
A team has used a process known as DNA origami to make electrochemical sensors that can quickly detect and measure biomarkers. Using an approach called DNA origami, scientists at Caltech have ...
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Officinae Bio's AI-driven sequence optimization expands Maravai's family of brands, enabling rapid, cost-effective nucleic acid therapy development Venice, Italy-based Officinae Bio's proprietary ...