enzymes that normally work to create a transient gate in a DNA duplex by breaking both strands via a covalent protein-DNA complex that is then reversed to reseal the break. Topoisomerase II is a key ...

The genetic connections between DNA repair ... AppDNA complex with structures of other bacterial ligases captured as the binary LigA• NAD + complex (step 1 substrate), binary LigA• NMN complex (the ...

In eukaryotes, the enzyme responsible for unzipping the DNA duplex during replication was originally identified as the minichromosome maintenance protein complex (MCM) genes from wine brewing ...

How did eukaryotic organisms become so much more complex than prokaryotic ... binding to the appropriate DNA strand, but also for interactions with other TFs, with proteins called coactivators ...