AZoLifeSciences on MSN8mon
Applications of Gene Knockout and Knock-in Models in Disease Researchand the Cas9 protein, which induces a DNA double-strand break (DSB) 2. Nuclease-induced DNA DSBs can be repaired through ...
The Cas9 endonuclease is guided by a single guide RNA (sgRNA) to a specific DNA sequence, where it creates a double-strand break. This break can then be repaired through either non-homologous end ...
For example, the PARP1 homology-directed repair (HDR) plasmid exploits the HDR pathway that enables precise DNA repair at the location of the CRISPR/Cas9 DSB site according to a targeted repair ...
(B, C) Confocal microscopic images of coronal brain sections of the hippocampus of Cas9 mice, showing the EGFP ... Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems ...
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