Epilepsy is a serious and common neurological condition, characterised by recurring, unprovoked seizures, affecting ...

May be affected by CYP450 inhibitors (eg, ketoconazole, erythromycin) or hepatic enzyme inducers (eg, glutethimide, phenobarbital); dose adjustments may be needed.

Additionally, the study evaluated the potential of theobromine N-3 demethylation to 7-methylxanthine as a CYP1A2 probe reaction in dogs, using recombinant canine CYP enzymes and liver microsomes from ...

PIFELTRO and DELSTRIGO are contraindicated when coadministered with drugs that are strong cytochrome P450 (CYP)3A enzyme inducers (including the anticonvulsants carbamazepine, oxcarbazepine, ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

Taking medications that strongly block the CYP3A4 enzyme Doctors typically will not prescribe Journavx in combination with a medication that strongly blocks the cytochrome p450 3A4 (CYP3A4) enzyme.

RAHWAY, N.J., July 10, 2025--U.S. FDA Accepts New Drug Application for Merck’s DOR/ISL Once-Daily Two-Drug Regimen for Treatment of Adults with Virologically Suppressed HIV-1.

PIFELTRO and DELSTRIGO are contraindicated when coadministered with drugs that are strong cytochrome P450 (CYP)3A enzyme inducers (including the anticonvulsants carbamazepine, oxcarbazepine ...

Appropriate healthcare utilization and compliance with the WHO treatment guidelines can significantly reduce diarrhea-related childhood mortality and morbidity, while overuse of antibiotics notably ...

Higher inhibition of cytochrome P450 enzymes can interfere with the metabolism of concurrently administered drugs, leading to increased systemic exposure, toxicity, and adverse clinical outcomes. In ...

Changes in epilepsy pharmacotherapy with non-enzyme inducing ASMs replacing older drugs has been implemented in Sweden and we detected a profound shift in the first ASM used in persons with incident ...