CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for ...

A new CRISPR screen method developed at Scripps Research has the potential to improve studies into the genetic underpinnings of human diseases and disorders. The method was outlined in Cell, in a ...

This review explores how NK cell senescence impacts cancer immunotherapy, highlighting key biomarkers like CD57 and reduced cytotoxicity. It reveals how the tumor microenvironment accelerates NK cell ...

Researchers found that, upon CAR T-cell therapy, microglia – the brain’s immune cells – produces chemicals like cytokines and chemokines as part of its inflammatory response.

Now, with the biotech eyeing up ways to keep the money flowing into 2026, the CRISPR-focused company has decided that the preclinical CAR-NK research needs to go—along with 12% of Caribou’s ...

Our transposon vector also encodes for secretion of the cytokine IL15 for increased persistence and function of CAR-NK cells. The SS1, 121, and M912 CAR NK cells with soluble IL15 (Armored-NK) were ...

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology ...

Editas tacks again, steering from lead sickle cell treatment to new one CRISPR pioneer to pursue more difficult, in-body treatment of cells Adobe By Jason Mast Oct. 22, 2024 General Assignment ...

Improving cancer-targeted CAR-T cells with safety-validated CRISPR prime editors "Currently, CAR-T cell therapy is approved for selected blood cancers. Our goal is to expand the application of CAR ...