This review explores how NK cell senescence impacts cancer immunotherapy, highlighting key biomarkers like CD57 and reduced cytotoxicity. It reveals how the tumor microenvironment accelerates NK cell ...

A new CRISPR screen method developed at Scripps Research has the potential to improve studies into the genetic underpinnings of human diseases and disorders. The method was outlined in Cell, in a ...

With the help of the CRISPR-Cas gene scissors, the researchers now want to protect CAR-T cells from elimination by NK cells in a clinical trial together with the Department of Haematology and ...

In Ba/F3 cell lines, sgRNA-mediated SHOC2 knockout led to pronounced cell lethality, with NRAS (Q61*) mutants exhibiting heightened sensitivity compared to KRAS (G12*)-mutant lines.

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for ...

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology ...

COLUMBUS, Ohio, May 6, 2025 /PRNewswire/ -- Andelyn Biosciences, Inc., a leading and patient-focused cell and gene therapy Contract Development and Manufacturing Organization (CDMO), has ...

Now, with the biotech eyeing up ways to keep the money flowing into 2026, the CRISPR-focused company has decided that the preclinical CAR-NK research needs to go—along with 12% of Caribou’s ...